|
KMID : 0616120210520010055
|
|
Korean Journal of Pharmacognosy
2021 Volume.52 No. 1 p.55 ~ p.60
|
|
|
Belamcandae Rhizoma Extract Improves Memory Impairment in Mice
|
|
Jung Ji-Wook
|
|
|
Abstract
|
|
|
|
Belamcandae Rhizoma (BR), the rhizome of Belamcanda chinensis (L.) DC., possesses various biological properties such as anti-inflammatory activity, antioxidant activity and antimutagenic activity. However, there have been no studies on the anti-amnesic effect of BR. In this study, we assessed the improvement effect of BR extract on scopolamine-induced amnesia in mice. ICR mice were administrated with BR (50, 100 or 200 mg/kg, p.o.) and were subsequently injected of scopolamine (1 mg/kg, i.p.) 30 min before behavioral tasks (Y-maze, passive avoidance and Morris water maze tasks). To further assess the possible mechanisms of BR, the ex vivo acetylcholinesterase (AChE) activity was also evaluated. BR could ameliorate scopolamine-induced memory impairment and could regulate the cholinergic function by inhibiting the AChE activity. These data demonstrated that BR exert candidate extract against amnesia by restoring the cholinergic activity.
|
|
|
KEYWORD
|
|
|
Belamcanda chinensis, Belamcandae Rhizoma, Scopolamine, Memory, Dementia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|